5 FiveLetterWords
Accepted guess Not a possible answer C tier for first-turn info

LYSIN

LYSIN is accepted as a guess but is not on the solver's possible-answer list.

As an opener, it rules out about 92.6% of possible answers.

Open Solver with LYSIN Open Word Finder

Meaning and pronunciation

Pronunciation: /ˈlaɪsɪn/

Noun

any substance or antibody that can cause the destruction (by lysis) of blood cells, bacteria etc

Source: Wiktionary contributors · CC BY-SA 4.0. Corrections.

Wordle status

A word can be a playable guess without being a possible answer.

Playable guess

Yes

Included in the Wordle guess list used by our tools.

Possible answer

No

The solver does not currently treat this as a possible answer.

Past Wordle answer

Not used yet

No past answer date found.

The possible-answer list is the solver's current list and may change when Wordle adds new answers.

How LYSIN performs as a guess

Wordle accepts LYSIN as a guess, but the solver does not list it as a possible answer.

Played as an opener, it lands at least one colored tile in 80.3% of games, misses completely in 19.7%, and leaves about 176 possible answers on average.

In the previous complete opener benchmark, it ranks #3,375 of 14,855 openers, averaging 3.64 guesses in games solved within six turns.

Try your feedback pattern

Tap the tiles to match your feedback, then see the ranked follow-up guesses.

All gray? Tap a tile to cycle gray → yellow → green.
See strategy patterns

Useful pattern pages

If you only know part of the word, start with one of these matching patterns.

L___N L in the 1st position and N in the 5th position L__I_ L in the 1st position and I in the 4th position _Y__N Y in the 2nd position and N in the 5th position

Explore lists that match the beginning, ending or letters in LYSIN.

First-turn measures

All four describe LYSIN used as an opening guess. Entropy is the same idea as “avg ruled out” on a log scale: a higher number means the guess splits the possible answers into more, smaller groups.

4.67 Entropy (bits)
176 Avg remaining
0.0% Exact match
92.6% Avg ruled out
Higher first-turn entropy than about 63% of evaluated openers
1.27 bits below the highest measured first-turn entropy (~5.95 bits)

As an opening guess: previous benchmark

How LYSIN performed in the previous complete opener benchmark, against its captured answer snapshot. These research figures are separate from today's solver recommendations. See the data page for the method.

3.64 Avg guesses
99.96% Solved within six
0.69 Spread of game lengths
#3,375 Rank among openers
Opening with LYSIN left 1 of the snapshot's answers unsolved after six guesses. A spread of 0.69 means those games clustered within about 0.69 of a guess of the 3.64 average. It ranks #3,375 of 14,855 openers by average guesses in games solved within six.
1 guess
0
2 guesses
54
3 guesses
952
4 guesses
1,144
5 guesses
186
6 guesses
17
Top-ranked in the current bounded policy screen: SLANT. The policy minimizes misses within six first, then average guesses among wins (3.46 for the leader). Compare the ranking measures

Composition

5/5 unique
1 vowels
Common:
ILNS

Feedback chances

Any hit (G/Y)
80%
Green tile
18%
All gray
20%

Feedback distribution

LYSIN can come back 92 different ways. These are the most likely, and how many of the possible answers give each one:

468 answers
234 answers
220 answers
141 answers
138 answers
124 answers
73 answers
72 answers
68 answers
63 answers
57 answers
56 answers
49 answers
43 answers
41 answers
40 answers
32 answers
29 answers
26 answers
26 answers
25 answers
19 answers
18 answers
17 answers
16 answers
15 answers
15 answers
14 answers
14 answers
13 answers

Letter-value totals

Base letter-value totals for LYSIN; these do not show whether either game accepts the word.

Scrabble

L1Y4S1I1N1
Total: 8 points

Words With Friends

Total: 9 points

Scores shown are base values without double/triple letter or word bonuses.

Try next

TRACE STRAE ROATE TRADE TRICE GRATE

Strategy after playing LYSIN

What the solver recommends next for each way the board can respond to LYSIN.

Quick reference

Largest feedback groups after playing LYSIN:

20% chance
Suggested:
TRACE
10% chance
Suggested:
STRAE
9% chance
Suggested:
ROATE

Follow-ups for common patterns

Ranked follow-up guesses for the 10 most common feedback patterns.

19.7% →
TRACE 6.42 bits
9.9% →
STRAE 5.79 bits
9.3% →
ROATE 5.29 bits
5.9% →
TRADE 4.92 bits
5.8% →
TRICE 5.39 bits
5.2% →
TRADE 5.36 bits
3.1% →
GRATE 4.60 bits
3.0% →
SHAPE 4.73 bits
2.9% →
CARET 5.10 bits
2.7% →
RAILE 4.34 bits

Research on LYSIN

Game-tree analysis and word research for LYSIN, with an explanation for each figure.

Optimal play

Opening with LYSIN, a proven-optimal strategy averages 3.70 guesses and ranks #4,970 of 14,855 legal openers. The best proven opener, TARSE, averages 3.55.

In hard mode it averages 3.84 guesses at best and is rank #2,538 of the 7,453 openers that can still guarantee a solve within six guesses.

Our six-turn simulation says 3.64, at or below the proven-optimal 3.70, because the two figures score different answer lists.

These figures come from exhaustive game-tree search and are exact for the NYT lists of July 2023 (3,158 answers). They do not use the site's working answer pool.

How it sounds

Two syllables, stress on the first syllable Say it LYSUHN. Estimated pronunciation

This pronunciation is machine-estimated, not taken from a pronunciation dictionary.

Related meanings

In WordNet's sense inventory, LYSIN is a kind of substance.

Familiarity and learning

Frequency
LYSIN sits in the rare band of the wordfreq scale, appearing less than once per million words of written English; the band marks it as a word few players will have met in print.

Sources: Optimal-play values: Alex Selby's exhaustive Wordle analysis (MIT); Pronunciation: CMU Pronouncing Dictionary (BSD), with machine estimates from the g2p_en model; Word relations: Open English WordNet, 2025 edition (CC BY 4.0); Word frequency: wordfreq (data CC BY-SA 4.0).